Endocrine Abstracts

Sex hormone-binding globulin (SHBG) is characterized by the unique ability of regulating estrogen free fraction and cross-talking with estradiol pathways in breast cancer cells, therefore reducing breast cancer cell growth and proliferation. In addition, the presence of the D327N (Asp327Asn, rs6259) single nucleotide polymorphism (SNP) of SHBG exon 8 confers a protective role to SHBG in breast cancer. Another polymorphism that has been receiving quite a lot of at...